Central vein sign for multiple sclerosis: A systematic review and meta-analysis
A Bhandari, H Xiang, J Lechner-Scott, M Agzarian - Clinical Radiology, 2020 - Elsevier
AIMS To systematically review the diagnostic value of the central vein sign (CVS) in multiple
sclerosis (MS) and to meta-analyse the proportion of positive lesions for CVS needed to
distinguish MS from non-MS mimics. MATERIALS AND METHODS A literature review was
performed and a proportion meta-analysis was performed to examine the proportion of the
CVS in MS lesions. Studies reporting a threshold of the CVS containing lesions with 100%
diagnostic accuracy were included in the meta-analysis. This was compared to MS mimics in …
sclerosis (MS) and to meta-analyse the proportion of positive lesions for CVS needed to
distinguish MS from non-MS mimics. MATERIALS AND METHODS A literature review was
performed and a proportion meta-analysis was performed to examine the proportion of the
CVS in MS lesions. Studies reporting a threshold of the CVS containing lesions with 100%
diagnostic accuracy were included in the meta-analysis. This was compared to MS mimics in …
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