… The cerebellum is particularly vulnerable to neurotoxic agents and poisoning. People of all
… Purkinje neurons are a main target of cerebellotoxic substances. The main causes of TOICS …

… in mind the list of agents that may cause cerebellar deficits, … aware of the list of agents that
could cause cerebellar deficits … This rule is valid for many cerebellotoxic agents. Intrauterine …

Clinical findings Phenytoin is the anticonvulsant drug which is the most frequently implicated
in drug-induced cerebellar ataxia. Toxicity develops either during chronic treatment or as a …

… Purkinje neurons are the main target of cerebellotoxic agents. The most common toxic
agent is ethanol. Cerebellotoxic drugs include antiepileptics, antineoplastics, lithium salts, and …

… Amongst cerebellotoxic agents, ethanol is the most commonly implicated. The vermis is a …
In addition to ethanol and drugs, environmental agents are also a source of TOICS. In particular…

… This rule is valid for many cerebellotoxic agents. Intrauterine exposure to phenytoin has been
associated with pontocerebellar hypoplasia (… Cerebellotoxic insecticides and herbicides …

… Minnelide is an experimental antineoplastic agent that is currently the subject of a phase
1 … Minnelide and compared its radiological manifestations with other cerebellotoxic agents. …

… Illicit drug use (especially amphetamines and cocaine) and the use of agents that can be
associated with neuroleptic malignant syndrome identify other populations at greater risk. …

… The most common cerebellotoxic agent is alcohol. Chronic consumption leads to
cerebellar atrophy which is most pronounced in the anterior vermis [95]. The principal neuropa…

… The most common cerebellotoxic agent is alcohol [25, 26]. Immune-mediated ataxias
include multiple sclerosis, cerebellar ataxia with antiglutamic acid decarboxylase antibodies, …