ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data
Abstract ChIPOTle (Chromatin ImmunoPrecipitation On Tiled arrays) takes advantage of two
unique properties of ChIP-chip data: the single-tailed nature of the data, caused by specific
enrichment but not specific depletion of genomic fragments; and the predictable enrichment
of DNA fragments adjacent to sites of direct protein-DNA interaction. Implemented as a
Microsoft Excel macro written in Visual Basic, ChIPOTle uses a sliding window approach
that yields improvements in the identification of bona fide sites of protein-DNA interaction.
unique properties of ChIP-chip data: the single-tailed nature of the data, caused by specific
enrichment but not specific depletion of genomic fragments; and the predictable enrichment
of DNA fragments adjacent to sites of direct protein-DNA interaction. Implemented as a
Microsoft Excel macro written in Visual Basic, ChIPOTle uses a sliding window approach
that yields improvements in the identification of bona fide sites of protein-DNA interaction.
Abstract
ChIPOTle (Chromatin ImmunoPrecipitation On Tiled arrays) takes advantage of two unique properties of ChIP-chip data: the single-tailed nature of the data, caused by specific enrichment but not specific depletion of genomic fragments; and the predictable enrichment of DNA fragments adjacent to sites of direct protein-DNA interaction. Implemented as a Microsoft Excel macro written in Visual Basic, ChIPOTle uses a sliding window approach that yields improvements in the identification of bona fide sites of protein-DNA interaction.
Springer
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