This chapter presents physical barriers, lack of adequate funding, poor supervision, delay in feedback, communication difficulties, negative attitudes, and impairment-related disadvantages as the unique challenges confronted by students with disabilities when doing research in higher education in South Africa. Data were collected through scanning South African and international literature available on Google scholar, ProQuest, in books, journal articles, and online resources. Informed by decolonial theory, the invisible underlying causes of the challenges are discussed. Suitable assistive devices, listening to students with disabilities' voices, and more time allocation are suggested as strategies that could improve research engagement for students with disabilities.