One of the most fascinating features of the hippocampus is its capacity for plasticity. Long-
term potentiation (LTP), a stable facilitation of synaptic potentials after high-frequency
synaptic activity, is very prominent in hippocampus and is a leading candidate memory
storage mechanism. Here, we discuss the nature and causes of LTP and relate them to
endogenous rhythmic neuronal activity patterns and their potential roles in memory.
Anatomical studies indicate that LTP is accompanied by postsynaptic structural …