Background Multimorbidity is associated with mortality and service use, with specific types of
multimorbidity having differential effects. Additionally, multimorbidity is often negatively
associated with participation in research cohorts. Therefore, we set out to identify clusters of
multimorbidity patients and how they are differentially associated with mortality and service
use across age groups in a population-representative sample. Methods Linked primary and
secondary care electronic health records contributed by 382 general practices in England to …

Background Multimorbidity is a major challenge facing health systems. To help understand
the changes to services and policies that are required, we investigated which diseases co-
occur and which combinations lead to the highest mortality and service use. Methods For
this population-based study, we used linked primary and secondary care electronic health
records contributed by general practices in England to the Clinical Practice Research
Datalink (CPRD). The study includes all multimorbid adults (aged≥ 18 years) with two or …