Characterization and immunogenicity of pyrogenic mitogens SePE-H and SePE-I of Streptococcus equi

SC Artiushin, JF Timoney, AS Sheoran… - Microbial …, 2002 - Elsevier
Two pyrogenic mitogens, SePE-H and SePE-I, were characterized in Streptococcus equi,
the cause of equine strangles. SePE-H and SePE-I have molecular masses of 27.5 and 29.5
kDa, respectively, and each is almost identical to its counterpart in Streptococcus pyogenes
M1. Both genes are adjacent to a gene encoding a phage muramidase of 49.7 kDa and are
located immediately downstream from a phage genomic sequence almost identical to a
similar phage sequence in S. pyogenes M1. Strong mitogenic responses were elicited by …
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