Carboxypeptidase N (CPN) is a plasma zinc metalloprotease comprised of two small
subunits that have enzymatic activity, and two large subunits, which protect the enzyme from
degradation. CPN cleaves the carboxyl-terminal amino acids arginine and lysine from
biologically active peptides such as complement anaphylatoxins, kinins, and fibrinopeptides.
To delineate the murine CPN small subunit coding region, gene structure, and chromosome
location, cDNA and genomic clones were isolated, characterized, and used in Northern and …

Characterization of the mouse carboxypeptidase N small active subunit gene structure …
Characterization of the mouse carboxypeptidase N small active subunit gene structure …