… proteasome targeting is rationalized by the existence of 2 types of direct proteasome signals
… modifications, which are recognized by proteasome regulatory subunits. Historically, the first …

… This work suggests that size, charge, surface coating, and shape of nanoparticles may … in
20S proteasome activity. Small nanoparticles may stimulate greater 20S proteasome activity …

… occurs when all 19S capped proteasome complexes are depleted. … of targeting disordered
proteins for degradation by regulating the dynamic equilibrium between different proteasome …

… Treatment of the 26S proteasome with compound 2 did not affect 26S-mediated … -mediated
proteolysis is consistent with our proposed binding of 2 to the α-ring of the 20S proteasome, …

… of targeted protein degradation through direct substrate recruitment to the 26S proteasome.
The … expressed in all cells; however, proteasomal ligands remain scarce. We identify potent …

… 20S a better target for these diseases. (34,35) Here, we discuss approaches that have been
implemented in increasing both 20S and 26S proteasome-mediated proteolysis, challenges …

… polypeptide micelles (Dar-PMs) mediate the targeted delivery of CFZ to CD38-positive MM,
… The antibody-targeted nanodelivery of a proteasome inhibitor appears to be an appealing …

… reaction involves ionic interactions between the positively charged amino groups of chitosan
and the negatively charged phosphate groups of TPP resulting in polymeric NPs (Fig. 1.A)…

… Still, the resource remains largely untapped since all proteasometargeting drugs used so far
in … of targeting PPI in the hub enzyme for intracellular protein catabolism, the proteasome. …

… proteasome, and the 20S proteasome degrades target proteins in a B 3 A-dependent
manner. Thus, we propose that B 3 A binding localizes the target protein to the 20S proteasome, …