The present investigation was conducted to assess the chemical composition and antioxidant properties of six local edible macrofungi ie, Agaricus bisporus, Coprinus atramentarius, Ganoderma lucidum, Morchella esculanta, Pleurotus ostreatus and Verpa bohemica. The proximate composition of these macrofungi with respect to protein, carbohydrate, fat, moisture and ash contents {limit values (%); average} revealed to be 25.56-36.18, 39.96-50.01, 1.40-2.70, 4.12-11.07 and 8.02-13.87, respectively. The element content (mg/100 g dw) in macrofungal samples ranged from 1950-2260 for K, 120-460 for P, 8-10 for Ca, 20-60 for Mg, 28-76 for Na 5.2-84.2 for Fe, 1.07-8.66 for Cu, 4.25-9.46 for Zn, 1.29-3.49 for Mn, 0.35-0.55 for Ni, 0.112-0.218 for Pb and 0.008-0.089 for Cd. The edible wild mushrooms were assessed for their anti-oxidant activity in three different solvents and antioxident properties of methanol-, ethanol-and distilled waterextracts studied by 1, 1-diphenyl 2-picrylhydrazyl (DPPH) free radical scavenging method. Maximum antioxidant activity was shown by Agaricus bisporus (87.0%) in methanol solvent and minimum activity in Ganoderma lucidum (83.5%). Hence, these nutrient contents revealed that mushrooms were low energy, healthy food and may also be used as a protein supplementary diet. This paper sums up diverse beneficial health effects of mushrooms to humans, in the form of proteins, carbohydrates, fats, minerals, food and drugs and medicines.