Chondroitin sulfate proteoglycan and its degradation products in CNS repair

A Rolls, M Schwartz - Advances in pharmacology, 2006 - Elsevier
Publisher Summary Increased levels of chondroitin sulfate proteoglycan (CSPG)
characterize responses to various types of tissue injury both in the periphery and in the
central nervous system (CNS). In the periphery, CSPG secretion following insult has been
associated with the repair process, while in the CNS, it is mainly thought to inhibit
regeneration. Central nervous system repair is a highly complicated process; neural tissue
has low tolerance to any deviation from homeostasis and it is characterized with intensive …
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