Proteoglycans are of two main types, chondroitin sulfate (CSPGs) and heparin sulfate
(HSPGs). The CSPGs act mainly as barrier-forming molecules, whereas the HSPGs stabilise
the interactions of receptors and ligands. During development CSPGs pattern cell migration,
axon growth pathways and axon terminations. Later in development and in adulthood
CSPGs associate with some classes of neuron and control plasticity. After damage to the
nervous system, CSPGs are the major axon growth inhibitory component of the glial scar …

Chondroitin sulfate proteoglycans (CSPGs) are major components of extracellular matrix in
the central nervous system (CNS), and play important roles in the development and
maintenance of CNS, as welt in pathogenesis or repair processes of neuronal damages.
They mainly exert barrier function for neuronal migration and axonogenesis during
development and inhibitory effects on plasticity and axon re-growth in the adult nerve
system. Digestion of glycosaminoglycan (GAG) chains or suppression of their synthesis …