… study, done at 87 sites in 13 countries, we recruited patients with stable, symptomatic chronic
heart failure and left ventricular … Patients were randomly assigned equally, via an interactive …

… contractility impairment is at the core of heart failure … Omecamtiv mecarbil activates cardiac
myosin and augments the … In summary, COSMIC-HF showed that an omecamtiv mecarbil PK-…

… trial of oral OM in chronic systolic HF, COSMIC-HF (Chronic Oral Study of Myosin Activation
to Increase Contractility in Heart … Results of COSMIC-HF will surely determine the future …

… COSMIC-HF (Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure…
a novel selective cardiac myosin activator, was associated with increased systolic ejection …

… The results of this study showed that in heart failure patients … Omecamtiv mecarbil activates
cardiac myosin and increases … of COSMICHF confirmed the improvement in cardiac function …

… contractility in heart failure with reduce ejection fraction. … has been studied in patients with
chronic heart failure as well … COSMIC-HF compared achievement of omecamtiv mecarbil …

… on symptoms and HRQL in patients with chronic heart failure with reduced ejection …
COSMIC-HF trial (Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure…

… directly activating the enzymatic pathway in the cardiac myocyte as a way to improve ventricular
contraction. … than the patients enrolled in GALACTIC-HF and COSMICHF. Both previous …

… Teerlink JR Chronic oral study of myosin activation to increase contractility in heart failure(COSMIC-HF):
final results from a double-blind, randomized, placebo-controlled, multicenter …

… of cardiac myosin, to be employed in heart failure treatment. … Through the cardiac myosin
activation, OM induces the … The purpose of COSMIC-HF trial was to investigate whether …