… function, as well as decreases in heart rate and NT-proBNP in the Chronic Oral Study …
Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF) 9 and the reduced heart …

… COSMIC-HF and ATOMIC-AHF pose several questions relating to the future of myosin activation
… Acute treatment with omecamtiv mecarbil to increase contractility in acute heart failure: …

… selective activation of the actin and myosin interaction could enhance contractility without …
OM was first tested for efficacy in a phase II study called COSMIC-HF, in which patients with …

… and oral administration, and in both acute and chronic settings … contractility as well as
rapidity of contraction. … on NT-proBNP and ventricular remodeling in COSMIC-HF are also …

… activators constitute a new class of drugs capable of increasing cardiac contractility …
patients with reduced ejection fraction (HFrEF) heart failure enrolled in the COSMIC-HF study…

… COSMIC-HF (Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure…
(LV) systolic function and ventricular remodeling in patients with heart failure with reduced …

… cardiac myosin activator that increases cardiac contractility … in the COSMIC-HF trial enrolled
448 outpatients with chronic … The COSMIC-HF (Chronic Oral Study of Myosin Activation to …

… axis activation and cardiac remodelling as compensatory mechanisms that ultimately result
in chronic heart failure … Although myosin activators increase contractility in a selective manner …

… This review discusses an evolutionary mechanism designed to regulate cardiac
contraction … , the Chronic Oral Study of Myosin Activation to Increase Contractility in HF (COSMIC-HF) …