… concentrations similar to those applied in this latter study. The possibility that OM may
lead … Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF…

… and myosin, which is essential for cardiac contractility [60]. … activate the cardiac isoform of
myosin, promoting cardiac … The COSMIC-HF study provided additional data on the effect of …

… of systolic heart failure, increasing cardiac contractility in the … with chronic heart failure and
reduced ejection fraction (… cycle of cardiac myosin has been described, to date, no study has …

… Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF …
Earlier drugs that directly activate sarcomere contractility target myosin and the troponin …

… and absence of the heart failure drug omecamtive mecarbil (… the myosin power stroke
occurs to generate contractile force. … α-cardiac myosin demonstrated a decrease in actin-activated …

… the Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMICHF) …
to assess the pharmacokinetics and effects of omecamtiv mecarbil on cardiac function. …

… to selectively activate the S1 domain of cardiac myosin and … studied in COSMIC-HF, which
randomized 448 patients with … and treatment of acute and chronic heart failure: the Task Force …

… myosin molecules participate in contraction at maximal tetanic stimulation. As a result, 232
OM increases force by higher activation … Contractility in Heart Failure (COSMIC-HF): a phase 2…

… An oral dosage modified release formulation is also being evaluated in COSMIC –HF (Chronic
Oral Study of Myosin Activation to Increase Contractility in Heart Failure) [18]. Whether the …