Circular permutation describes a type of relationship between proteins, whereby the proteins
have … to the mathematical notion of a cyclic permutation over the set of residues in a protein. …

Circular permutation (CP) in a protein can be considered as if its sequence were circularized
followed by a creation of termini at a new location. Since the first observation of CP in 1979, …

… proteins is defined to be related by a circular permutation if the N-terminal region of one protein
… To detect pairs of proteins that might be related by circular permutation, we implemented …

… circular permutation (CP) (throughout this paper we use the terms circular permutations and
cyclic permutations … Two proteins are related by a CP when a fragment in the C-terminal part …

… chain of a protein by circular permutation (CP). By connecting the native protein termini via a
… , CP can perturb local tertiary structure and protein dynamics, as well as introduce possible …

… generation of (~rcuiar and circularly permuted protein variants in vitro. The trypsin inhibitor
… yield a circularly permuted protein form. Both the circular and the permuted variant were able …

… describes a relationship between two proteins where the N-terminal portion of one protein is
… permuted proteins are generally found to assume the same structure. Circular permutation …

… design mutations that enhance protein activity, specificity, or … the protein sequence composition
subtly, circular permutation … of the protein engineering toolkit to redesign proteins, with …

Circular permutation (CP) refers to situations in which the termini of a protein are relocated …
CP occurs naturally and has been artificially created to study protein function, stability and …

… circular permutants is only n − 1. Because circular permutation has been reported for many
proteins … study should be generally applicable to many proteins. We hope that application of …