Clinical and pathologic features of lung cancer expressing programmed cell death ligand 1 (PD-L1)
M Shimoji, S Shimizu, K Sato, K Suda, Y Kobayashi… - Lung cancer, 2016 - Elsevier
Background Programmed cell death 1 (PD-1) negatively regulates antigen receptor
signaling upon binding by either of its ligands, programmed cell death ligand 1 or 2 (PD-
L1/2). Blockade of this interaction with either PD-1 or PD-L1 antibodies has been successful
in the treatment of human cancer, especially melanoma and non-small cell lung cancer. PD-
L1 expression has been proposed as a predictor of tumor response. However, the
relationships between PD-L1 expression and various clinicopathological characteristics …
signaling upon binding by either of its ligands, programmed cell death ligand 1 or 2 (PD-
L1/2). Blockade of this interaction with either PD-1 or PD-L1 antibodies has been successful
in the treatment of human cancer, especially melanoma and non-small cell lung cancer. PD-
L1 expression has been proposed as a predictor of tumor response. However, the
relationships between PD-L1 expression and various clinicopathological characteristics …
[PDF][PDF] Clinical and pathologic features of lung cancer expressing programmed cell death ligand 1 (PD-L1)
下治正樹， シモジマサキ - 博士学位論文/本文(平成29 年度授与), 2018 - kindai.repo.nii.ac.jp
Background: Programmed cell death 1 (PD-1) negatively regulates antigen receptor
signaling upon binding by either of its ligands, programmed cell death ligand 1 or 2 (PD-
L1/2). Blockade of this interaction with either PD-1 or PD-L1 antibodies has been successful
in the treatment of human cancer, especially melanoma and non-small cell lung cancer. PD-
L1 expression has been proposed as a predictor of tumor response. However, the
relationships between PD-L1 expression and various clinicopathological characteristics …
signaling upon binding by either of its ligands, programmed cell death ligand 1 or 2 (PD-
L1/2). Blockade of this interaction with either PD-1 or PD-L1 antibodies has been successful
in the treatment of human cancer, especially melanoma and non-small cell lung cancer. PD-
L1 expression has been proposed as a predictor of tumor response. However, the
relationships between PD-L1 expression and various clinicopathological characteristics …
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