This study was conducted at the Patuakhali Science and Technology University Veterinary Clinic, Babugonj, Barisal during the period from January 2008 to December 2011 to report the four years clinical diseases of ruminants. A total of 1241 clinical cases (793 cattle and 448 goats) were recorded and analyzed. Diagnosis of each of the clinical cases was made on clinical history, clinical signs, and faecal examination for parasitic cases. The clinical cases were primarily categorized into three major groups, namely,(1) Medicinal,(2) Gynaeco-obstetrical and (3) Surgical cases. Medicinal cases constituted highest percentage (cattle 84.1% and goats 81.0%) in comparison to gynaeco-obstetrical (cattle 4.7% and goats 1.1%) and surgical (cattle 11.2% and goats 17.9%) cases. Among the medicinal cases in cattle, highest percentage of cases was recorded with parasitic diseases (50.4%), followed by general systemic states (14.8%) and digestive disorders (14.2%). Other cases were respiratory disorders (5.5%), infectious diseases (4.6%), skin conditions (3.4%), eye disease (3.1%), urogenital disorders (1.5%), metabolic diseases (1.3%) and musculo-skeletal disorders (0.9%). In case of goats, the highest cases was recorded with digestive disorders (22.9%), followed by parasitic diseases (20.4%) and respiratory disorders (16.8%). Other Medicinal cases in goats were eye diseases (13.5%), infectious diseases (11.8%), general systemic states (9.6%), musculo-skeletal disorder (3.3%), skin diseases (0.8%) and nutritional deficiency diseases (0.8%). Among the gynaeco-obstetrical cases, anestrus (59.5%) in cattle and metritis (40.0%) in goats were recognized as the major gynaeco-obstetric problems. Traumatic wounds (cattle-52.8%, goat-28.8%) and castration (31.3%) in goats were recognized as the main disorders which required surgical interventions. It may be concluded that a number of diseases with various percentages have been occurring in the Babugonj upazila and this report will help to prioritize any control measures against major disease conditions reported in this study. However, it is required to estimate the prevalence of diseases in the population of that upazila to have more comprehensive information on the diseases of cattle and goat.