Importance Lewy bodies are a frequent coexisting pathology in late-onset Alzheimer
disease (AD). Previous studies have examined the contribution of Lewy bodies to the clinical
phenotype of late-onset AD with variable findings. Objective To determine whether the
presence of Lewy body pathology influences the clinical phenotype and progression of
symptoms in longitudinally assessed participants with AD. Design, Setting, and Participants
Retrospective clinical and pathological cohort study of 531 deceased participants who met …