Interindividual variability in response to drugs used in anesthesia has long been considered
the rule, not the exception. It is important to mention that in anesthesiology, the variability in
response to drugs is multifactorial, ie, genetic and environmental factors interact with each
other and thus affect the metabolism, efficacy, and side effects of drugs. Propofol (2, 6-
diisopropylphenol) is the most common intravenous anesthetic used in modern medicine.
Individual differences in genetic factors [single nucleotide polymorphisms (SNPs)] in the …