Clinical linear accelerator-based electron FLASH: pathway for practical translation to FLASH clinical trials
Purpose Ultrahigh-dose-rate (UHDR) radiation therapy (RT) has produced the FLASH effect
in preclinical models: reduced toxicity with comparable tumor control compared with
conventional-dose-rate RT. Early clinical trials focused on UHDR RT feasibility using
specialized devices. We explore the technical feasibility of practical electron UHDR RT on a
standard clinical linear accelerator (LINAC). Methods and Materials We tuned the program
board of a decommissioned electron energy for UHDR electron delivery on a clinical LINAC …
in preclinical models: reduced toxicity with comparable tumor control compared with
conventional-dose-rate RT. Early clinical trials focused on UHDR RT feasibility using
specialized devices. We explore the technical feasibility of practical electron UHDR RT on a
standard clinical linear accelerator (LINAC). Methods and Materials We tuned the program
board of a decommissioned electron energy for UHDR electron delivery on a clinical LINAC …
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