Clinical pharmacology of lacidipine

ST Hall, SM Harding, GL Evans… - … pharmacology, 1991 - journals.lww.com
… Each received a single 4-mg oral dose of lacidipine and an intravenous infusion of 400 pug
of lacidipine over 30 min in a randomized crossover study. A comparison of the determined …

Safety profile of lacidipine: a review of clinical data

CA Endersby, EG Brown… - … pharmacology, 1991 - journals.lww.com
… Summary: The clinical safety of the new dihydropyridine calcium antagonist lacidipine was
assessed in 14 clinical trials, including 1,372 patients treated with lacidipine and 687 treated …

Clinical position of lacidipine, a new dihydropyridine calcium antagonist, in the treatment of hypertension

G Leonetti - Journal of cardiovascular pharmacology, 1991 - journals.lww.com
… In other specific trials, lacidipine has been shown to have a … We conclude that lacidipine
is an effective antihypertensive … Furthermore, lacidipine is able to reverse the early changes …

Lacidipine: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of hypertension

C Rhoda Lee, HM Bryson - Drugs, 1994 - Springer
… These reactions occurred in 5.2 to 14.1% of patients treated with lacidipine in 14 clinical
of adverse effects with lacidipine is dose-related: 41 % of patients receiving lacidipine 4 mg/day …

Dose linearity of lacidipine pharmacokinetics after single and repeated oral doses in healthy volunteers

LD Ros, L Squassante, S Milleri - Clinical pharmacokinetics, 2003 - Springer
… The study was performed in the internal GSK Clinical Pharmacology Unit in Verona in
compliance with current Italian laws. All related study costs were funded by GSK Italy. …

The effects of lacidipine on the steady/state plasma concentrations of simvastatin in healthy subjects

L Ziviani, L Da Ros, L Squassante… - … pharmacology, 2001 - Wiley Online Library
… simvastatin and lacidipine as they share the CYP3A4 metabolic pathway and the combination
of dihydropyridines with cholesterol lowering agents seems to be clinically appropriate. …

Lacidipine: a review of its use in the management of hypertension

PL McCormack, AJ Wagstaff - Drugs, 2003 - Springer
… [8] The purpose of this review is to update the appraisal of the clinical properties of lacidipine
with important new data that have become available since the original review, especially …

An assessment of lacidipine and atenolol in mild to moderate hypertension.

D Lyons, G Fowler, J Webster, ST Hall… - … clinical pharmacology, 1994 - Wiley Online Library
… of lacidipine when prescribed with atenolol (lacidipine was no evidence that there had been
… ng ml-' vs lacidipine/atenolol 3.018 + of lacidipine upon repeated dosing with the lacidipine/ …

Lacidipine: effects on vascular pressor responses throughout the dosage interval in normotensive subjects

S Ueda, R Donnelly, V Panfilov… - … pharmacology, 1998 - Wiley Online Library
… to assess the relative magnitude of the pharmacological activity of calcium antagonist drugs
… multiple dosing with lacidipine in this study there was an obvious pharmacological effect at …

Metabolic effects of lacidipine: a placebo-controlled study using the euglycaemic hyperinsulinaemic clamp.

AD Morris, R Donnelly, JM Connell… - … of clinical pharmacology, 1993 - ncbi.nlm.nih.gov
Clinical Investigation and Research Unit (CIRU) to evaluate theeffects of acute andchronic
lacidipine … the contralateral arm, and then lacidipine or placebo was administered orally with …