… Monoclonality of pituitary adenomas would, thus, favor a somatic … rior pituitary cells respond
to increased exogenous growth-promoting stimuli. The clonal nature of pituitary adenomas …

… Analysis of the DNA revealed that, in each of the three pituitary tumors, one X chromosome
… these tumors was monoclonal in origin. It is concluded that clinically evident pituitary tumors …

… tissue clonality, and has demonstrated that the majority of sporadic human pituitary adenomas
… tumours arise from de novo somatic genetic change(s) in a single pituitary cell. However, …

… Little is known about the pathogenesis of pituitary neoplasia. Clonal analysis allows oneto
make … We investigated the clonal origin of pituitary tumors using X-linked restriction fragment …

… incidentally found pituitary adenomas, the data on clinically relevant pituitary adenomas
argue … can contain multiple tumours or hyperplastic areas – each with its own clonal origin and …

… the key mechanism protecting pituitary adenomas turning malignant in the … Here we briefly
summarize the genetic background of pituitary adenomas, … Clonal origin of pituitary adenomas …

… arise from the same clone or have individually distinct clonal origins. Given what … pituitary
adenomas (see below) we predict that each discrete adenoma will have a different clonal origin…

… pituitary adenomas can be observed in AIP gene mutation-positive cases and in X-linked
acrogigantism due to GPR101 duplications, but in most familial isolated pituitary adenomas, …

… tissue from all 10 women with morphologically and immunohistochemically confirmed
ACTH-secreting pituitary microadenomas demonstrated a monoclonal pattern. Pathologically …

… Thus, we suggest that recurrent human pituitary tumors arise from a separate independent
clone in a significant proportion of cases (up to 60%), although within the same operative …