Clonal origin of pituitary adenomas
V HERMAN, J FAGIN, R GONSKY… - The Journal of …, 1990 - academic.oup.com
… Monoclonality of pituitary adenomas would, thus, favor a somatic … rior pituitary cells respond
to increased exogenous growth-promoting stimuli. The clonal nature of pituitary adenomas …
to increased exogenous growth-promoting stimuli. The clonal nature of pituitary adenomas …
Clonal origin of pituitary adenomas
LB Jacoby, ET Hedley-Whyte, K Pulaski… - Journal of …, 1990 - thejns.org
… Analysis of the DNA revealed that, in each of the three pituitary tumors, one X chromosome
… these tumors was monoclonal in origin. It is concluded that clinically evident pituitary tumors …
… these tumors was monoclonal in origin. It is concluded that clinically evident pituitary tumors …
Pituitary tumour clonality revisited
RN Clayton, WE Farrell - Molecular Pathology of the Pituitary, 2004 - karger.com
… tissue clonality, and has demonstrated that the majority of sporadic human pituitary adenomas
… tumours arise from de novo somatic genetic change(s) in a single pituitary cell. However, …
… tumours arise from de novo somatic genetic change(s) in a single pituitary cell. However, …
Clinically nonfunctioning pituitary tumors are monoclonal in origin.
JM Alexander, BM Biller, H Bikkal… - The Journal of …, 1990 - Am Soc Clin Investig
… Little is known about the pathogenesis of pituitary neoplasia. Clonal analysis allows oneto
make … We investigated the clonal origin of pituitary tumors using X-linked restriction fragment …
make … We investigated the clonal origin of pituitary tumors using X-linked restriction fragment …
The epidemiology and genetics of pituitary adenomas
… incidentally found pituitary adenomas, the data on clinically relevant pituitary adenomas
argue … can contain multiple tumours or hyperplastic areas – each with its own clonal origin and …
argue … can contain multiple tumours or hyperplastic areas – each with its own clonal origin and …
Novel genetic causes of pituitary adenomas
F Caimari, M Korbonits - Clinical Cancer Research, 2016 - AACR
… the key mechanism protecting pituitary adenomas turning malignant in the … Here we briefly
summarize the genetic background of pituitary adenomas, … Clonal origin of pituitary adenomas …
summarize the genetic background of pituitary adenomas, … Clonal origin of pituitary adenomas …
Clonality of pituitary tumours: more complicated than initially envisaged?
RN Clayton, WE Farrell - Brain Pathology, 2001 - Wiley Online Library
… arise from the same clone or have individually distinct clonal origins. Given what … pituitary
adenomas (see below) we predict that each discrete adenoma will have a different clonal origin…
adenomas (see below) we predict that each discrete adenoma will have a different clonal origin…
Genetic aspects of pituitary adenomas
P Marques, M Korbonits - Endocrinology and Metabolism …, 2017 - endo.theclinics.com
… pituitary adenomas can be observed in AIP gene mutation-positive cases and in X-linked
acrogigantism due to GPR101 duplications, but in most familial isolated pituitary adenomas, …
acrogigantism due to GPR101 duplications, but in most familial isolated pituitary adenomas, …
Clonal origins of adrenocorticotropin-secreting pituitary tissue in Cushing's disease
BM Biller, JM Alexander, NT Zervas… - The Journal of …, 1992 - academic.oup.com
… tissue from all 10 women with morphologically and immunohistochemically confirmed
ACTH-secreting pituitary microadenomas demonstrated a monoclonal pattern. Pathologically …
ACTH-secreting pituitary microadenomas demonstrated a monoclonal pattern. Pathologically …
Different patterns of allelic loss (loss of heterozygosity) in recurrent human pituitary tumors provide evidence for multiclonal origins
RN Clayton, M Pfeifer, AB Atkinson, P Belchetz… - Clinical cancer …, 2000 - AACR
… Thus, we suggest that recurrent human pituitary tumors arise from a separate independent
clone in a significant proportion of cases (up to 60%), although within the same operative …
clone in a significant proportion of cases (up to 60%), although within the same operative …
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