Coenzyme B12 can be produced by engineered Escherichia coli under both anaerobic and aerobic conditions
Y Ko, S Ashok, SK Ainala… - Biotechnology …, 2014 - Wiley Online Library
Abstract Coenzyme B12 (Vitamin B12) is one of the most complex biomolecules and an
essential cofactor required for the catalytic activity of many enzymes. Pseudomonas
denitrificans synthesizes coenzyme B12 in an oxygen‐dependent manner using a pathway
encoded by more than 25 genes that are located in six different operons. Escherichia coli, a
robust and suitable host for metabolic engineering was used to produce coenzyme B12.
These genes were cloned into three compatible plasmids and expressed heterologously in …
essential cofactor required for the catalytic activity of many enzymes. Pseudomonas
denitrificans synthesizes coenzyme B12 in an oxygen‐dependent manner using a pathway
encoded by more than 25 genes that are located in six different operons. Escherichia coli, a
robust and suitable host for metabolic engineering was used to produce coenzyme B12.
These genes were cloned into three compatible plasmids and expressed heterologously in …
Coenzyme B12 can be produced by engineered Escherichia coli under both anaerobic and aerobic conditions.
KYJ Ko YeounJoo, SA Somasundar Ashok, SK Ainala… - 2014 - cabidigitallibrary.org
Abstract Coenzyme B12 (Vitamin B12) is one of the most complex biomolecules and an
essential cofactor required for the catalytic activity of many enzymes. Pseudomonas
denitrificans synthesizes coenzyme B12 in an oxygen-dependent manner using a pathway
encoded by more than 25 genes that are located in six different operons. Escherichia coli, a
robust and suitable host for metabolic engineering was used to produce coenzyme B12.
These genes were cloned into three compatible plasmids and expressed heterologously in …
essential cofactor required for the catalytic activity of many enzymes. Pseudomonas
denitrificans synthesizes coenzyme B12 in an oxygen-dependent manner using a pathway
encoded by more than 25 genes that are located in six different operons. Escherichia coli, a
robust and suitable host for metabolic engineering was used to produce coenzyme B12.
These genes were cloned into three compatible plasmids and expressed heterologously in …
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