Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension: a double‐blind randomized controlled trial
TM MacDonald, B Williams, DJ Webb… - Journal of the …, 2017 - Am Heart Assoc
Background Guidelines for hypertension vary in their preference for initial combination
therapy or initial monotherapy, stratified by patient profile; therefore, we compared the
efficacy and tolerability of these approaches. Methods and Results We performed a 1‐year,
double‐blind, randomized controlled trial in 605 untreated patients aged 18 to 79 years with
systolic blood pressure (BP)≥ 150 mm Hg or diastolic BP≥ 95 mm Hg. In phase 1 (weeks 0–
16), patients were randomly assigned to initial monotherapy (losartan 50–100 mg or …
therapy or initial monotherapy, stratified by patient profile; therefore, we compared the
efficacy and tolerability of these approaches. Methods and Results We performed a 1‐year,
double‐blind, randomized controlled trial in 605 untreated patients aged 18 to 79 years with
systolic blood pressure (BP)≥ 150 mm Hg or diastolic BP≥ 95 mm Hg. In phase 1 (weeks 0–
16), patients were randomly assigned to initial monotherapy (losartan 50–100 mg or …
[PDF][PDF] Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial
JK Cruickshank, I Ford, P Sever, IS Mackenzie… - 2017 - research.ed.ac.uk
Background-—Guidelines for hypertension vary in their preference for initial combination
therapy or initial monotherapy, stratified by patient profile; therefore, we compared the
efficacy and tolerability of these approaches. Methods and Results-—We performed a 1-
year, double-blind, randomized controlled trial in 605 untreated patients aged 18 to 79 years
with systolic blood pressure (BP)≥ 150 mm Hg or diastolic BP≥ 95 mm Hg. In phase 1
(weeks 0–16), patients were randomly assigned to initial monotherapy (losartan 50–100 mg …
therapy or initial monotherapy, stratified by patient profile; therefore, we compared the
efficacy and tolerability of these approaches. Methods and Results-—We performed a 1-
year, double-blind, randomized controlled trial in 605 untreated patients aged 18 to 79 years
with systolic blood pressure (BP)≥ 150 mm Hg or diastolic BP≥ 95 mm Hg. In phase 1
(weeks 0–16), patients were randomly assigned to initial monotherapy (losartan 50–100 mg …
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