Common variants associated with plasma triglycerides and risk for coronary artery disease
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary
artery disease (CAD). However, it is unclear whether this association reflects causal
processes. We used 185 common variants recently mapped for plasma lipids (P< 5× 10− 8
for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci
associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and …
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary
artery disease (CAD). However, it is unclear whether this association reflects causal
processes. We used 185 common variants recently mapped for plasma lipids (P< 5× 10− 8
for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci
associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and …