When considering connexin expression and regulation, the epidermis of the skin is one of
the most complex tissues found in mammals even though it largely contains a single cell
type, the keratinocyte. In the rodent epidermis, up to 9 connexin family members have been
detected at the mRNA level. Many of these connexins are temporally and spatially regulated
in coordination with keratinocyte progenitor cell differentiation and migration from the
stratum basale to form the stratum spinosum and stratum granulosum layers before finally …