Although it is well known that micronuclei may arise from either DNA breakage leading to
acentric chromosome fragments or from chromosome/chromatid lagging in anaphase, the
ratio between the amount of DNA breakage induced and the frequency of micronuclei
expressed in the following interphase is unclear. With the development of the alkaline single
cell gel electrophoresis assay, which measures single strand and/or double strand breaks in
a cell by cell approach, it is now possible to address this question at the cellular level. We …