Realizing the full potential of drip irrigation technology requires optimizing the operational parameters that are available to irrigators, such as the frequency, rate, and duration of water application and the placement of drip tubing. Numerical simulation is a fast and inexpensive approach to studying optimal management practices. Unfortunately, little work has been done to investigate the accuracy of numerical simulations, leading some to question the usefulness of simulation as a research and design tool. In this study, we compare HYDRUS-2D simulations of drip irrigation with experimental data. A Hanford sandy loam soil was irrigated using thin-walled drip tubing installed at a depth of 6 cm. Three trials (20, 40, and 60 applied water) were carried out. At the end of each irrigation and approximately 24 h later, the water content distribution in the soil was determined by gravimetric sampling. The HYDRUS-2D predictions of the water content distribution are found to be in very good agreement with the data. The results support the use of HYDRUS-2D as a tool for investigating and designing drip irrigation management practices.