Purpose To compare the IVF outcome of clomiphene citrate/gonadotropin/antagonist (mild
protocol) and microdose GnRH agonist flare protocols for poor responders undergoing in
vitro fertilization. Methods 159 poor responder patients were randomized and ovarian
stimulation was performed with clomiphene citrate, gonadotropin and antagonist (group I) or
microdose GnRH agonist flare (group II) protocols. Main outcome was clinical pregnancy
rate and secondary outcomes were doses of gonadotropin administration and duration of …

Introduction: The poor responder is defined as patient with low ovarian reserve. The
response to controlled ovarian hyperstimulation (COH) is lower regarding estradiol (E2)
level, number of obtained oocytes, and fertilization, implantation and pregnancy rates in
patients with low ovarian reserve. Despite the progression in ART, the preferred protocol for
poor responders is still controversial. Several strategies are available to improve ART cycles
outcome in poor responders. Materials and Methods: To compare the IVF outcome of …