[HTML][HTML] Comparison of serum mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) levels in patients with multiple sclerosis and healthy controls

S Tekin, LS Bir, E Avci, H Şenol, I Tekin, U Çınkır - Cureus, 2022 - ncbi.nlm.nih.gov
S Tekin, LS Bir, E Avci, H Şenol, I Tekin, U Çınkır
Cureus, 2022ncbi.nlm.nih.gov
Background Multiple sclerosis (MS) is a major global problem, and as its pathogenesis is
understood more clearly, therapeutic options expand accordingly. The mitochondrial open
reading frame of the 12S rRNA-c (MOTS-c) is a novel mitochondria-derived protein acting on
metabolic homeostasis. In this study, we aimed to investigate the role of serum MOTS-c in
the pathophysiology of the disease in MS patients and to discuss the mechanism of MOTS-c.
Abstract
Background
Multiple sclerosis (MS) is a major global problem, and as its pathogenesis is understood more clearly, therapeutic options expand accordingly. The mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is a novel mitochondria-derived protein acting on metabolic homeostasis. In this study, we aimed to investigate the role of serum MOTS-c in the pathophysiology of the disease in MS patients and to discuss the mechanism of MOTS-c.
ncbi.nlm.nih.gov
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