Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development

S Subramaniam, K Jurk, L Hobohm… - Blood, The Journal …, 2017 - ashpublications.org
… the IVC thrombosis model to analyze the role of the complement system in venous thrombosis
The IVC was ligated to induce a flow restriction of ∼85% to 90%, which initiates thrombus

Interaction between the coagulation and complement system

U Amara, D Rittirsch, M Flierl, U Bruckner… - … topics in complement II, 2008 - Springer
… , that thrombin, generated at inflammatory sites in response to complement activation, is a …
preventing thrombosis during inflammation (Lidington et al. 2000). The complement activation …

Complement interactions with blood cells, endothelial cells and microvesicles in thrombotic and inflammatory conditions

D Karpman, A Ståhl, I Arvidsson, K Johansson… - Immune Responses to …, 2015 - Springer
inflammatory process but may also contribute to its propagation. This overview will describe
complement … during hemolytic uremic syndrome, thrombotic thrombocytopenic purpura and …

Complement activation, inflammation and relative ADAMTS13 deficiency in secondary thrombotic microangiopathies

P Farkas, D Csuka, B Mikes, G Sinkovits, M Réti… - Immunobiology, 2017 - Elsevier
… ULVWF to in vitro complement activation, we … thrombotic microangiopathies. Furthermore,
we also hypothesized that the presence of ULVWF may be associated with in vivo complement

Venous thromboembolism: thrombosis, inflammation, and immunothrombosis for clinicians

E Vazquez-Garza, C Jerjes-Sanchez… - Journal of thrombosis …, 2017 - Springer
… Evidence suggests that the complement system may serve as a link between inflammation
and thrombosis, revealing specific interactions between complement proteins and platelets. …

The case of complement activation in COVID-19 multiorgan impact

M Noris, A Benigni, G Remuzzi - Kidney international, 2020 - Elsevier
… In this review, we discuss the relative role of the different complement activation … inflammation
and thrombosis and propose the hypothesis that blockade of the terminal complement

Complement activation: an emerging player in the pathogenesis of cardiovascular disease

AM Carter - Scientifica, 2012 - Wiley Online Library
Complement activation also influences thrombosis, involving … the complement system in
inflammation and thrombosis is consistent with the physiological role of the complement system …

[HTML][HTML] Complement-mediated microvascular injury and thrombosis in the pathogenesis of severe COVID-19: A review

P Gianni, M Goldin, S Ngu, S Zafeiropoulos… - World Journal of …, 2022 - ncbi.nlm.nih.gov
… of the innate immune response and inflammation and thus an appealing … complement in
the development of thrombotic microangiopathy and summarize the current data on complement

Will complement inhibition be the new target in treating COVID-19–related systemic thrombosis?

CM Campbell, R Kahwash - Circulation, 2020 - Am Heart Assoc
… Coronavirus and complement.A, Simplified diagram of the common complement pathway.
Eculizumab … B, In humans, overactivation of the complement pathway can lead to thrombotic

[PDF][PDF] Blood coagulation-dependent inflammation. Coagulation-dependent inflammation and inflammation-dependent thrombosis

S Strukova - Front Biosci, 2006 - article.imrpress.com
… similar to the C-end of hirudin and complementary to the anion-binding exosite 1 (ABE1) in
… A negatively charged sequence capable of complementary interaction with the ABE1 of the …