… had elevated levels of complement biomarkers. Our findings suggested that APS patients
outside acute thrombosis might be divided into two clusters: "inflammatory" and "complement". …

… In severe cases of COVID-19, massive endothelial dysfunction, widespread coagulopathy
and complement-induced thrombosis can lead to the development of systemic …

… atherosclerotic lesion disruption with superimposed thrombus formation, is the … a
thrombotic risk clustering which is composed of hyper-reactive platelets, up regulation of pro-thrombotic …

… damage via release of inflammatory cytokines 14 . The complement system plays important
… However, unregulated complement activation causes severe inflammation 15,16 . Recent …

Hemostasis, thrombosis, and inflammation are tightly interconnected processes which may
give rise to thrombo-inflammation, involved in infectious and non-infectious acute and …

… between inflammation and deep vein thrombosis and thus the potential value of anti-inflammatory …
reaction through various mechanisms – particularly by dampening the complement …

… of complement. In TTP, severe ADAMTS13 deficiency leads to generation of massive platelet
thrombi, which might contribute to complement … targeting of complement with the anti-C5 …

… Another recent study provided evidence for complement activation in thrombotic APS as
well as … activated complement directly and contributed to thrombosis whereas mutations in …

… of cardiac thrombi can promote platelet aggregation (95). Interestingly, an increase of
complement C5a in the plasma of STEMI patients was recently connected to thrombus formation. …

… of thrombosis in these disorders. In this paper we will examine the mechanisms of thrombosis
and its relationship to complement activation review the effects of complement inhibition. …