Comprehensive analysis of scRNA-Seq and bulk RNA-Seq data reveals dynamic changes in tumor-associated neutrophils in the tumor microenvironment of …
D Yang, Y Zhou, Y Zhang, Y Su, J Shen, B Yu… - Cancer Immunology …, 2023 - Springer
Background Analysis of hepatocellular carcinoma (HCC) single-cell sequencing data was
conducted to explore the role of tumor-associated neutrophils in the tumor
microenvironment. Methods Analysis of single-cell sequencing data from 12 HCC tumor
cores and five HCC paracancerous tissues identified cellular subpopulations and cellular
marker genes. The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO)
databases were used to establish and validate prognostic models. xCELL, TIMER …
conducted to explore the role of tumor-associated neutrophils in the tumor
microenvironment. Methods Analysis of single-cell sequencing data from 12 HCC tumor
cores and five HCC paracancerous tissues identified cellular subpopulations and cellular
marker genes. The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO)
databases were used to establish and validate prognostic models. xCELL, TIMER …
Comprehensive analysis of scRNA-Seq and bulk RNA-Seq reveals dynamic changes in the tumor immune microenvironment of bladder cancer and establishes a …
Background The prognostic management of bladder cancer (BLCA) remains a great
challenge for clinicians. Recently, bulk RNA-seq sequencing data have been used as a
prognostic marker for many cancers but do not accurately detect core cellular and molecular
functions in tumor cells. In the current study, bulk RNA-seq and single-cell RNA sequencing
(scRNA-seq) data were combined to construct a prognostic model of BLCA. Methods BLCA
scRNA-seq data were downloaded from Gene Expression Omnibus (GEO) database. Bulk …
challenge for clinicians. Recently, bulk RNA-seq sequencing data have been used as a
prognostic marker for many cancers but do not accurately detect core cellular and molecular
functions in tumor cells. In the current study, bulk RNA-seq and single-cell RNA sequencing
(scRNA-seq) data were combined to construct a prognostic model of BLCA. Methods BLCA
scRNA-seq data were downloaded from Gene Expression Omnibus (GEO) database. Bulk …
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