Communication across membranes controls critical cellular processes and is achieved by
receptors translating extracellular signals into selective cytoplasmic responses. While
receptor tertiary structures can be readily characterized, receptor associations into
quaternary structures are challenging to study and their implications in signal transduction
remain poorly understood. Here, we report a computational approach for predicting receptor
self-associations, and designing receptor oligomers with various quaternary structures and …

Computationally designed GPCR quaternary structures bias signaling pathway activation …
Computationally designed GPCR quaternary structures bias signaling pathway activation …
Title Computationally designed GPCR quaternary structures bias signaling pathway activation …