Concise whole blood transcriptional signatures for incipient tuberculosis: a systematic review and patient-level pooled meta-analysis

RK Gupta, CT Turner, C Venturini, H Esmail… - The Lancet …, 2020 - thelancet.com
incipient tuberculosis. We aimed to compare the performance of systematically identified
candidate signatures for incipient tuberculosis and to benchmark these against WHO targets. …

S110 Concise whole blood transcriptional signatures for incipient tuberculosis: a systematic review and individual participant data meta-analysis

RK Gupta, CT Turner, C Venturini, H Esmail… - Thorax, 2019 - search.proquest.com
… We performed a systematic review to identify candidate mRNA signatures for incipient TB,
along … Methods We performed a systematic review to identify candi- date mRNA signatures for …

Performance of diagnostic and predictive host blood transcriptomic signatures for Tuberculosis disease: A systematic review and meta-analysis

H Mulenga, CZ Zauchenberger, EW Bunyasi… - PLoS …, 2020 - journals.plos.org
… of incipient TB. We present a systematic review and meta-analysis of transcriptomic … OR
gene expression OR genetic transcription OR host blood OR immune marker OR immunologic …

[HTML][HTML] Systematic review of diagnostic and prognostic host blood transcriptomic signatures of tuberculosis disease in people living with HIV

SC Mendelsohn, S Verhage, H Mulenga… - Gates Open …, 2023 - ncbi.nlm.nih.gov
… to measure the Sweeney3 signature 19, 49 in biobanked whole blood RNA samples. No
included studies validated signature performance for diagnosing extrapulmonary TB. However, …

Host blood transcriptomic biomarkers of tuberculosis disease in people living with HIV: a systematic review protocol

SC Mendelsohn, H Mulenga, SK Mbandi, F Darboe… - BMJ open, 2021 - bmjopen.bmj.com
… We aim to conduct a systematic review of performance of transcriptomic … . Concise whole
blood transcriptional signatures for incipient tuberculosis: a systematic review and patient-level …

Blood transcriptional biomarkers for active pulmonary tuberculosis in a high-burden setting: a prospective, observational, diagnostic accuracy study

CT Turner, RK Gupta, E Tsaliki, JK Roe… - The Lancet …, 2020 - thelancet.com
… candidate transcriptional signatures identified by systematic review, in a setting with a high
burden of tuberculosis and HIV. … Concise whole blood transcriptional signatures for incipient

Host blood-based biosignatures for subclinical TB and incipient TB: A prospective study of adult TB household contacts in Southern India

D Sivakumaran, S Jenum, A Srivastava… - Frontiers in …, 2023 - frontiersin.org
… A recent systematic review and meta-analysis evaluated 17 … host mRNA signatures in whole
blood with reasonable … eight concise signatures that differentiated incipient TB from healthy …

Blood transcriptomic signatures for symptomatic tuberculosis in an African multicohort study

VM Muwanga, SC Mendelsohn… - European …, 2024 - erj.ersjournals.com
… Background Multiple host blood transcriptional signatures … Transcriptomic signatures were
measured in whole blood using … RNA signatures [19–21], a systemic review of transcriptomic …

Headway made towards biosignatures for incipient tuberculosis

TJ Scriba, SC Mendelsohn - The Lancet Respiratory Medicine, 2020 - thelancet.com
Concise whole blood transcriptional signatures for incipient tuberculosis: a systematic review
… head-to-head comparison of the diagnostic accuracy of 27 blood transcriptional signatures. …

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection

A Singhania, R Verma, CM Graham, J Lee… - Nature …, 2018 - nature.com
Whole blood transcriptional signatures distinguishing active tuberculosis patients from …
within a short period of prospective observation, suggesting that incipient (or subclinical) TB is …