Content-dependent osteogenic response of nanohydroxyapatite: an in vitro and in vivo assessment within collagen-based scaffolds
GM Cunniffe, CM Curtin, EM Thompson… - … applied materials & …, 2016 - ACS Publications
The use of collagen-based scaffolds in orthopedic applications has been limited due to poor
mechanical properties, but this may be overcome by the introduction of a stiffer supporting
phase. Thus, we developed a synthesis technique to produce nonaggregating, stable
nanohydroxyapatite (nHA) particles, permitting the fabrication of biomimetic-inspired
scaffolds through the combination of nanosized HA with collagen, as found in native bone.
This study evaluates the mechanical and biological impact of incorporating increasing …
mechanical properties, but this may be overcome by the introduction of a stiffer supporting
phase. Thus, we developed a synthesis technique to produce nonaggregating, stable
nanohydroxyapatite (nHA) particles, permitting the fabrication of biomimetic-inspired
scaffolds through the combination of nanosized HA with collagen, as found in native bone.
This study evaluates the mechanical and biological impact of incorporating increasing …
[引用][C] Content-Dependent Osteogenic Response of Nanohydroxyapatite: An in Vitro and in Vivo Assessment within Collagen-Based Scaffolds
J O'Brien Fergal - 2016