Over the past few decades, the fundamental concept that the in vivo modulation of levels of
arachidonic acid (AA) is intimately linked to cellular function and human disease has been
firmly established [1-5]. A key regulatory event in most cell types is the mobilization of
esterified AA from cellular or dietary sources and the subsequent metabolism of this AA into
oxygen-containing metabolites (eicosanoids). Both AA and its metabolites then induce
fundamental biochemical events which alter numerous cell functions. While low levels of AA …