Corpus callosum abnormalities and their association with psychotic symptoms in patients with schizophrenia
BACKGROUND: While the neuroanatomical underpinnings of the functional brain
disconnectivity observed in patients with schizophrenia (SZ) remain elusive, white matter
fiber bundles of the brain are a likely candidate, given that they represent the infrastructure
for long-distance neural communication. METHODS: This study investigated for diffusion
abnormalities in 19 patients with chronic SZ, relative to 19 matched control subjects, across
tractography-defined segments of the corpus callosum. Diffusion-weighted images were …
disconnectivity observed in patients with schizophrenia (SZ) remain elusive, white matter
fiber bundles of the brain are a likely candidate, given that they represent the infrastructure
for long-distance neural communication. METHODS: This study investigated for diffusion
abnormalities in 19 patients with chronic SZ, relative to 19 matched control subjects, across
tractography-defined segments of the corpus callosum. Diffusion-weighted images were …
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