Correlation between the Elastase Activity Index and Invasiveness of Clinical Isolates of Aspergillus fumigatus
Journal of clinical microbiology, 2002•Am Soc Microbiol
We calculated an elastase activity index (EAI) by dividing the diameter of the elastin lysis
halo by the fungal growth diameter. After 10 days' incubation at 37° C, all strains but one
obtained from invasive aspergillosis showed an EAI≥ 1. Of the 18 strains obtained from
colonized patients, only 4 (22.2%) had an EAI≥ 1, whereas neither of the strains isolated
from patients with fungus ball reached this value. Overall, 44 out of the 142 strains obtained
from the environment had an EAI≥ 1 (30.9%).
halo by the fungal growth diameter. After 10 days' incubation at 37° C, all strains but one
obtained from invasive aspergillosis showed an EAI≥ 1. Of the 18 strains obtained from
colonized patients, only 4 (22.2%) had an EAI≥ 1, whereas neither of the strains isolated
from patients with fungus ball reached this value. Overall, 44 out of the 142 strains obtained
from the environment had an EAI≥ 1 (30.9%).
Abstract
We calculated an elastase activity index (EAI) by dividing the diameter of the elastin lysis halo by the fungal growth diameter. After 10 days' incubation at 37°C, all strains but one obtained from invasive aspergillosis showed an EAI ≥ 1. Of the 18 strains obtained from colonized patients, only 4 (22.2%) had an EAI ≥ 1, whereas neither of the strains isolated from patients with fungus ball reached this value. Overall, 44 out of the 142 strains obtained from the environment had an EAI ≥ 1 (30.9%).
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