Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging
J Krell-Roesch, M Vassilaki, MM Mielke… - Translational …, 2019 - nature.com
Neuropsychiatric symptoms (NPS) are a risk factor for cognitive impairment and are
associated with cortical β-amyloid (Aβ) deposition. We conducted a cross-sectional study
derived from the ongoing population-based Mayo Clinic Study of Aging to examine the
frequency of NPS among cognitively unimpaired (CU) and mild cognitive impairment (MCI)
participants who either have normal (A−) or abnormal (A+) Aβ deposition. We also
investigated whether combined presence of MCI and amyloid positivity (MCI/A+) is …
associated with cortical β-amyloid (Aβ) deposition. We conducted a cross-sectional study
derived from the ongoing population-based Mayo Clinic Study of Aging to examine the
frequency of NPS among cognitively unimpaired (CU) and mild cognitive impairment (MCI)
participants who either have normal (A−) or abnormal (A+) Aβ deposition. We also
investigated whether combined presence of MCI and amyloid positivity (MCI/A+) is …
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