Cosuspensions of microcrystals and engineered microparticles for uniform and efficient delivery of respiratory therapeutics from pressurized metered dose inhalers
R Vehring, D Lechuga-Ballesteros, V Joshi, B Noga… - Langmuir, 2012 - ACS Publications
Engineered porous phospholipid microparticles with aerodynamic diameters in the
respirable range of 1–2 μm were cosuspended in 1, 1, 1, 2-tetrafluoroethane, a propellant,
with microcrystals of glycopyrrolate, formoterol fumarate dihydrate, or Mometasone furoate
three drugs with different solubilities in the propellant, and different physical, chemical, and
pharmacological attributes. The drug microcrystals were added individually, in pairs, or all
three together to prepare different cosuspensions, contained in a pressurized metered dose …
respirable range of 1–2 μm were cosuspended in 1, 1, 1, 2-tetrafluoroethane, a propellant,
with microcrystals of glycopyrrolate, formoterol fumarate dihydrate, or Mometasone furoate
three drugs with different solubilities in the propellant, and different physical, chemical, and
pharmacological attributes. The drug microcrystals were added individually, in pairs, or all
three together to prepare different cosuspensions, contained in a pressurized metered dose …
[引用][C] Cosuspensions of Microcrystals and Engineered Microparticles for Uniform and Efficient Delivery of Respiratory Therapeutics from Pressurized Metered Dose …
V Reinhard, LB David, J Vidya, N Brian - 2012
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