To date there is no accepted clinical diagnostic test for Parkinson's disease (PD) based on
biochemical analysis of blood or cerebrospinal fluid (CSF). α‐Synuclein (α‐syn) protein has
been linked to the pathogenesis of PD with the discovery of mutations in the gene encoding
α‐syn in familial cases with early‐onset PD. Lewy bodies and Lewy neurites, which
constitute the main pathological features in the brains of patients with sporadic PD and
dementia with Lewy bodies, are formed by the conversion of soluble monomers of α‐syn into …