This paper presents “Craniux,” an open‐access, open‐source software framework for brain‐machine interface (BMI) research. Developed in LabVIEW, a high‐level graphical programming environment, Craniux offers both out‐of‐the‐box functionality and a modular BMI software framework that is easily extendable. Specifically, it allows researchers to take advantage of multiple features inherent to the LabVIEW environment for on‐the‐fly data visualization, parallel processing, multithreading, and data saving. This paper introduces the basic features and system architecture of Craniux and describes the validation of the system under real‐time BMI operation using simulated and real electrocorticographic (ECoG) signals. Our results indicate that Craniux is able to operate consistently in real time, enabling a seamless work flow to achieve brain control of cursor movement. The Craniux software framework is made available to the scientific research community to provide a LabVIEW‐based BMI software platform for future BMI research and development.