Creation of a mixed poly (ethylene glycol) tethered-chain surface for preventing the nonspecific adsorption of proteins and peptides
K Uchida, Y Hoshino, A Tamura, K Yoshimoto… - …, 2007 - pubs.aip.org
Using a heterotelechelic poly (ethylene glycol)(PEG) possessing a mercapto group at one
end and an acetal group at the other end (acetal-PEG-SH), the authors constructed a
reactive PEG tethered-chain surface on a surface plasmon sensor (SPR) gold chip for
biosensing with high sensitivity. Nonspecific bovine serum albumin adsorption on the PEG
tethered-chain surface was significantly influenced by the density of the PEG chain, and was
almost completely suppressed by increasing the PEG density through the repetitive …
end and an acetal group at the other end (acetal-PEG-SH), the authors constructed a
reactive PEG tethered-chain surface on a surface plasmon sensor (SPR) gold chip for
biosensing with high sensitivity. Nonspecific bovine serum albumin adsorption on the PEG
tethered-chain surface was significantly influenced by the density of the PEG chain, and was
almost completely suppressed by increasing the PEG density through the repetitive …
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