[HTML][HTML] Critical role of lipid composition in membrane permeabilization by rabbit neutrophil defensins
We have examined the interactions of the six known rabbit neutrophil defensin antimicrobial
peptides with large unilamellar vesicles (LUV) made from various lipid mixtures based on
the lipid composition of Escherichia coli membranes. We find that the permeabilization of
LUV made from E. coliwhole lipid extracts differs dramatically from that of single-component
LUV made from palmitoyl-oleoyl-phosphatidylglycerol (POPG). Specifically, defensins NP-1,
NP-2, NP-3A, NP-3B, and a natural mixture of the six defensins cause fast nonpreferential …
peptides with large unilamellar vesicles (LUV) made from various lipid mixtures based on
the lipid composition of Escherichia coli membranes. We find that the permeabilization of
LUV made from E. coliwhole lipid extracts differs dramatically from that of single-component
LUV made from palmitoyl-oleoyl-phosphatidylglycerol (POPG). Specifically, defensins NP-1,
NP-2, NP-3A, NP-3B, and a natural mixture of the six defensins cause fast nonpreferential …
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