Lead (Pb) is one of the ten most public health concern chemicals identified by World health organization (WHO). It is mostly present in Pb²⁺ form and enlisted in one of the most toxic having metals having capability to cause tumour. An excellent sensor, N′-[(E)-(2-hydroxynaphthalen-1-yl) methylidene] benzenesulfonohydrazide (HNMBSH) for Pb²⁺, is synthesized by following a simple condensation approach where 2-hydroxynaphthalene and benzene sulfonylhydrazide were reacted equi-molar in ethanol. The title compound was collected in very good yield and crystallized in ethanol. The structure was determined by ¹H NMR, ¹³C NMR, UV/vis, FT-IR and single crystal X-ray diffraction. HNMBSH was fabricated on flat-glassy carbon electrode (GCE) with nafion i.e.; a conducting binder in phosphate buffer phase and used as Pb²⁺ short response time sensor. The fabricated HNMBSH/Nafion/GCE sensor is exhibited higher sensitivity, large-dynamic concentration ranges, long-term stability, and improved electrochemical performances towards Pb²⁺ ions. The calibration plot is linear over the large Pb²⁺ concentration ranges (0.1 nM to 1.0 mM). The sensitivity, detection limit and limit of quantification of this newly proposed method are found to be ∼3.956 µA mM⁻¹ cm⁻², ∼0.024 nM (signal-to-noise ratio, at a SNR of 3) and 0.08 nM respectively. This novel effort is initiated a well-organize way of efficient HNMBSH/Nafion/GCE sensor development with conducting binder deposited GCE for toxic heavy cationic pollutants in environmental and health-care fields in broad scales. Therefore, the HNMBSH/Nafion/GCE sensor offers a cost effective organic ligand that can be considered as a viable alternative for effectively detecting and removing hazardous and carcinogenic Pb²⁺ from real water samples.