Over the past decade, antimicrobial resistance has emerged as a major public health crisis.
Glycopeptide antibiotics such as vanco-mycin and teicoplanin are clinically important for the
treatment of Gram-positive bacterial infections. StaL is a 3′-phosphoadenosine 5′-
phosphosulfate-dependent sulfotransferase capable of sulfating the cross-linked
heptapeptide substrate both in vivo and in vitro, yielding the product A47934, a unique
teicoplanin-class glycopeptide antibiotic. The sulfonation reaction catalyzed by StaL …