[PDF][PDF] Crystal structure of human eIF5A1: insight into functional similarity of human eIF5A1 and eIF5A2
Y Tong, I Park, BS Hong, L Nedyalkova… - Proteins: Structure …, 2009 - drive.google.com
Eukaryotic initiation factor 5A (eIF5A) plays an essential role in the viability of eukaryotic
cells. 1–3 eIF5A is known to act as a translation initiation factor specific for a small number of
mRNAs, 4–6 a cellular target of HIV-1 REV protein, 7 and an exportin-4-dependent nuclear
export cargo. 8 eIF5A is also involved in mRNA turnover9, 10 and the establishment of actin
polarity. 11 A single lysyl residue of eIF5A is post-translationally modified to the unusual
amino acid hypusine, involving two enzymes12, 13: deoxyhypusine synthase (DHS) …
cells. 1–3 eIF5A is known to act as a translation initiation factor specific for a small number of
mRNAs, 4–6 a cellular target of HIV-1 REV protein, 7 and an exportin-4-dependent nuclear
export cargo. 8 eIF5A is also involved in mRNA turnover9, 10 and the establishment of actin
polarity. 11 A single lysyl residue of eIF5A is post-translationally modified to the unusual
amino acid hypusine, involving two enzymes12, 13: deoxyhypusine synthase (DHS) …
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