Cu-catalyzed one-pot synthesis of unsymmetrical diaryl thioethers by coupling of aryl halides using a thiol precursor

DJC Prasad, G Sekar - organic letters, 2011 - ACS Publications
DJC Prasad, G Sekar
organic letters, 2011ACS Publications
An efficient Cu-catalyzed one-pot approach for the synthesis of unsymmetrical diaryl
thioethers using potassium ethyl xanthogenate as a thiol surrogate is developed. This new
protocol avoids usage of intricate thiols and makes use of its easily available xanthate as a
precursor, and thiol will be generated in situ to prepare the diaryl thioethers through a Cu-
catalyzed double arylation. This strategy was further successfully utilized for the synthesis of
symmetrical diaryl thioethers, aryl alkyl thioethers, and benzothiazoles.
An efficient Cu-catalyzed one-pot approach for the synthesis of unsymmetrical diaryl thioethers using potassium ethyl xanthogenate as a thiol surrogate is developed. This new protocol avoids usage of intricate thiols and makes use of its easily available xanthate as a precursor, and thiol will be generated in situ to prepare the diaryl thioethers through a Cu-catalyzed double arylation. This strategy was further successfully utilized for the synthesis of symmetrical diaryl thioethers, aryl alkyl thioethers, and benzothiazoles.
ACS Publications
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